GSK-3 inhibitor 3

Research use only, not for human use.

GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively.

GSK-3 inhibitor 3 is a selective, orally active and brain-penetrant inhibitor of GSK-3, with IC50s of 0.35 nM and 0.25 nM for GSK-3α and GSK-3β, respectively. GSK-3 inhibitor 3 lowers levels of tau protein phosphorylation at S396 in a triple-transgenic mouse Alzheimer’s disease model, with IC50 of 10 nM. GSK-3 inhibitor 3 can be used for neurological disease research.

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Others

Other Targets

Microtubule Associated | GSK-3

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2227279-84-5

410.4

C23H15FN6O

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (121.83 mM; Ultrasonic )

N(C(=O)C1=NC(NC2=CC=C(C#N)C=C2)=NC=C1)C=3C(=CC=NC3)C4=CC=C(F)C=C4

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(-20℃)

With Ice Pack

≥ 2 years